NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme present in all living cells, serving as a central mediator of cellular energy production and metabolic regulation. Research investigations have focused on its role as a substrate for sirtuins (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and CD38 — enzymes involved in DNA repair, gene expression, and calcium signaling.
In preclinical and clinical models, NAD+ supplementation has been studied for its effects on mitochondrial biogenesis and oxidative phosphorylation efficiency. Research has examined the age-related decline of intracellular NAD+ levels and its correlation with metabolic dysfunction, neurodegeneration, and impaired DNA repair capacity. Additional investigations have explored NAD+ precursors and direct supplementation for improving exercise performance, insulin sensitivity, and circadian rhythm regulation.
Supplied as a lyophilized powder for reconstitution. Intended for research purposes only.
