Dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) is a seven-amino-acid peptide first isolated from the skin secretions of Phyllomedusa sauvagei frogs. It is notable in research for containing a D-amino acid (D-alanine), which is rare among naturally occurring peptides in vertebrates. Research investigations have focused on its exceptionally high affinity and selectivity for the mu-opioid receptor.
In research settings, dermorphin has been studied as a pharmacological tool for understanding opioid receptor signaling and analgesic mechanisms. Published investigations have examined its binding characteristics, which demonstrate significantly greater potency than morphine at the mu-opioid receptor. Studies have explored its unique biosynthetic pathway and its utility as a reference compound in opioid receptor research.
Supplied as a lyophilized powder for reconstitution. Intended for research purposes only.
